Phenotypes Associated with This Genotype

Genotype
MGI:3844608

• Allelic Composition: Hoxc4^tm2.1Mrc/Hoxc4^tm2.1Mrc
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:148278 )

N • unlike in mice homozygous for Hoxc4^tm1Mrc, mice exhibit no increase in postnatal lethality

immune system

immune system phenotype ( J:148278 )

N • mice exhibit normal B cell, T cell, CD4+ T cell numbers, death of B cells and T cells in the spleens and Peyer's patches, and B cell cycle, division, and germinal center formation

abnormal class switch recombination ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines, class switch recombination is reduced compared to in wild-type mice

• however, germ line transcription of the intervening heavy chain and constant heavy chain is normal, and forced expression of Aicda (AID) restores class switch recombination

abnormal somatic hypermutation frequency ( J:148278 )

• fewer mutations are observed compared to in wild-type mice

decreased IgA level ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines

decreased IgE level ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines

decreased IgG1 level ( J:148278 )

• unimmunized mice exhibit lower than normal IgG1 serum levels

• following immunization with NP16-CGG, mice exhibit reduced total IgG1 serum levels, NP30-binding and NP3-binding IgG1 compared to in similarly treated wild-type mice

decreased IgG2a level ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines

decreased IgG2b level ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines

decreased IgG3 level ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines

decreased IgM level ( J:148278 )

• following immunization with NP16-CGG, mice exhibit slightly lower NP3-binding IgM compared to in similarly treated wild-type mice

hematopoietic system

abnormal class switch recombination ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines, class switch recombination is reduced compared to in wild-type mice

• however, germ line transcription of the intervening heavy chain and constant heavy chain is normal, and forced expression of Aicda (AID) restores class switch recombination

abnormal somatic hypermutation frequency ( J:148278 )

• fewer mutations are observed compared to in wild-type mice

decreased IgA level ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines

decreased IgE level ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines

decreased IgG1 level ( J:148278 )

• unimmunized mice exhibit lower than normal IgG1 serum levels

• following immunization with NP16-CGG, mice exhibit reduced total IgG1 serum levels, NP30-binding and NP3-binding IgG1 compared to in similarly treated wild-type mice

decreased IgG2a level ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines

decreased IgG2b level ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines

decreased IgG3 level ( J:148278 )

• following B cell stimulation with LPS or LPS plus cytokines

decreased IgM level ( J:148278 )

• following immunization with NP16-CGG, mice exhibit slightly lower NP3-binding IgM compared to in similarly treated wild-type mice