Hoxc4^tm2.1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxc4^tm2.1Mrc
• Name: homeobox C4; targeted mutation 2.1, Mario R Capecchi
• MGI ID: MGI:3844593
• Gene: Hoxc4 Location: Chr15:102927366-102945278 bp, + strand Genetic Position: Chr15, 58.08 cM
• Alliance: Hoxc4^tm2.1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148278
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted into exon 2 into the homeodomain. Germ line, cre mediated recombination removed the neo cassette. Expression of Hoxc5 and Hoxc6 is unaltered unlike in other knock-out alleles. (J:148278)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxc4 Mutation: 8 strains or lines available

References

• Original: J:148278 Park SR, et al., HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nat Immunol. 2009 May;10(5):540-50
• All: 1 reference(s)