Analysis Tools
immune system
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• mice infected with L. mexicana develop an enhanced Th1 response as evidenced by increased IL-2, IL-12 and IFN-gamma secretion
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• N. brasiliensis infection leads to high numbers of intestinal mucosal mast cells
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• mice produce significantly less IgE in response to L. mexicana infection
• L. mexicana-specific IgE is three-fold less than controls
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• N. brasiliensis infection leads to higher levels of IgE than in infected-controls
• higher IgE levels might be due to the chronic infection that occurs in these mice as opposed to the acute infection that occurs in controls
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• mice produce 2-log fold less IgG1 in response to L. mexicana infection
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• N. brasiliensis infection leads to higher levels of IgG1 than in infected-controls
• higher IgG1 levels might be due to the chronic infection that occurs in these mice as opposed to the acute infection that occurs in controls
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• mice produce 2-log fold more IgG2a in response to L. mexicana infection
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• lymphocytes stimulated with L. mexicana antigen produce vastly more IFN-gamma than wild-type controls
(J:51096)
• restimulation of lymphocytes from Ova-immunized mice leads to enhanced IFN-gamma secretion
(J:96338)
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• lymphocytes stimulated with L. mexicana antigen produce 5-fold more IL-12 than wild-type controls
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• restimulation of lymphocytes from Ova-immunized mice fails to solicit an IL-4 response
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• mice exhibit a milder form of low dose streptozotocin (STZ)-induced diabetes with blood glucose levels that lower than those of controls
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• 15 days after inoculation with N. brasiliensis, intestines contain large numbers of adult worms while controls have expelled the worms by this time point
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hematopoietic system
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• mice infected with L. mexicana develop an enhanced Th1 response as evidenced by increased IL-2, IL-12 and IFN-gamma secretion
|
|
• N. brasiliensis infection leads to high numbers of intestinal mucosal mast cells
|
|
• mice produce significantly less IgE in response to L. mexicana infection
• L. mexicana-specific IgE is three-fold less than controls
|
|
• N. brasiliensis infection leads to higher levels of IgE than in infected-controls
• higher IgE levels might be due to the chronic infection that occurs in these mice as opposed to the acute infection that occurs in controls
|
|
• mice produce 2-log fold less IgG1 in response to L. mexicana infection
|
|
• N. brasiliensis infection leads to higher levels of IgG1 than in infected-controls
• higher IgG1 levels might be due to the chronic infection that occurs in these mice as opposed to the acute infection that occurs in controls
|
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• mice produce 2-log fold more IgG2a in response to L. mexicana infection
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integument
skin lesions
(
J:51096
)
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• mice fail to develop significant skin lesions in response to Leishmania mexicana infection
• some inflammatory foci comprised primarily of lymphocytes and macrophages and only a few parasites are visible in mutant mice compared to tissue destruction with diffuse inflammatory infiltrate consisting of heavily parasitized macrophages, eosinophils, and lymphocytes
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