Phenotypes for Map3k5 Map3k6 MGI:3844019 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Map3k5^tm1Hijo/Map3k5^tm1Hijo Map3k6^tm1Hijo/Map3k6^tm1Hijo
Genetic Background	B6.129-Map3k6^tm1Hijo Map3k5^tm1Hijo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k5^tm1Hijo mutation (4 available); any Map3k5 mutation (62 available)
Map3k6^tm1Hijo mutation (3 available); any Map3k6 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:148044 )

• hyperplasia following TPA exposure is milder than in wild type controls or mice homozygous for Map3k6^tm1Hijo alone

neoplasm

neoplasm ( J:148044 )

N	• unlike mice homozygous for Map3k6^tm1Hijo alone, no increase in chemically induced skin tumorigenesis is detected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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