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Phenotypes Associated with This Genotype
Genotype
MGI:3842819
Allelic
Composition
Tg(TcraR28,TcrbR28)KRNDim/0
Genetic
Background
involves: C57BL/6 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophage cells make up a large number of cells found in inflamed joints
• clonal deletion is evident in the thymus of neonatal mice with reduced numbers of total cells and aberrant percentages of single-positive populations
• single-positive populations normalize by 4 weeks of age though total cell numbers are still reduced
• clonal deletion affects T cell populations in the periphery with a paucity of single-positive T cells in young mice and chronically reduced CD4+ population in adults
• spleen and lymph node B cell numbers are increased 1.75-fold in mice suffering from arthritis
• CD4+ T cells are virtually absent in the spleens of mice under 2 weeks of age
• CD4+ T cell numbers are reduced by 3.1-fold in the spleens of adult mice
• CD8 +T cells numbers are reduced in mice under 3 weeks of age
• splenomegaly is often observed
• neutrophils make up a large number of cells found in inflamed joints
• serum IgG1 levels are dramatically increased
• a greater proportion of T cells express late activation markers (CD44hi CD62Llo, CD45RBlo) than in transgene negative controls
• T cells expressing the transgenic TCR proliferate in response to antigen presenting cells expressing Class II MHC from a H2g7 locus in the absence of any antigen
• Background Sensitivity: transgenic T cells from mice on a NOD background have lower levels of T cell receptor expressed
• Background Sensitivity: transgenic T cells from mice on a NOD background have a severe reduction in response to its cognate antigen (RNAse peptide) presented by Ak than do transgenic T cells from a C57BL/6 background
• hybridomas created from these T cells respond normally to antigen suggesting a cell intrinsic anergy
• Background Sensitivity: transgenic mice crossed to a NOD background develop rheumatoid arthritis
• distal paws become red and swollen
• all transgenic mice have significantly swollen ankles by 30 days of age with the degree of swelling symmetrical on either limb
• as mice age hyperextension of the ankle, valgus deviation of the knee and hyperpronation of the toes occur
• arthritis occurs in almost all joints with the exception of hip joints
• arthritis starts as fibrinoid material and a few cells are found in the articular cavity; edema sets in under the synovial lining, accompanied by neovascularithezation and some infiltration of inflammatory cells
• after a few weeks, disease is marked by extensive synovitis, affecting all areas of the joint with massive infiltration of inflammatory cells and beginnings of fibrosis
• after several months, the inflammation recedes leaving massive fibrosis, very little cartilage, and irregular shaped bone
• occurs as part of arthritis disease process
• immunoglobulin deposits occur along the peritubular basal membranes in the cortex and medulla
• immunoglobulin deposits are detected in the glomeruli

limbs/digits/tail
• bones are eroded from arthritis with anarchic reconstruction occurring afterwards
• rheumatoid arthritis leads to hyperpronation of the toes
• bones are eroded from arthritis with anarchic reconstruction occurring afterwards

skeleton
• Background Sensitivity: transgenic mice crossed to a NOD background develop rheumatoid arthritis
• distal paws become red and swollen
• all transgenic mice have significantly swollen ankles by 30 days of age with the degree of swelling symmetrical on either limb
• as mice age hyperextension of the ankle, valgus deviation of the knee and hyperpronation of the toes occur
• arthritis occurs in almost all joints with the exception of hip joints
• arthritis starts as fibrinoid material and a few cells are found in the articular cavity; edema sets in under the synovial lining, accompanied by neovascularithezation and some infiltration of inflammatory cells
• after a few weeks, disease is marked by extensive synovitis, affecting all areas of the joint with massive infiltration of inflammatory cells and beginnings of fibrosis
• after several months, the inflammation recedes leaving massive fibrosis, very little cartilage, and irregular shaped bone
• occurs as part of arthritis disease process
• bones are eroded from arthritis with anarchic reconstruction occurring afterwards
• bones are eroded from arthritis with anarchic reconstruction occurring afterwards
• intervertebral inflammation occurs sporadically in these mice
• mobility is compromised due to arthritis

renal/urinary system
• immunoglobulin deposits occur along the peritubular basal membranes in the cortex and medulla
• immunoglobulin deposits are detected in the glomeruli

hematopoietic system
• macrophage cells make up a large number of cells found in inflamed joints
• clonal deletion is evident in the thymus of neonatal mice with reduced numbers of total cells and aberrant percentages of single-positive populations
• single-positive populations normalize by 4 weeks of age though total cell numbers are still reduced
• clonal deletion affects T cell populations in the periphery with a paucity of single-positive T cells in young mice and chronically reduced CD4+ population in adults
• spleen and lymph node B cell numbers are increased 1.75-fold in mice suffering from arthritis
• CD4+ T cells are virtually absent in the spleens of mice under 2 weeks of age
• CD4+ T cell numbers are reduced by 3.1-fold in the spleens of adult mice
• CD8 +T cells numbers are reduced in mice under 3 weeks of age
• splenomegaly is often observed
• neutrophils make up a large number of cells found in inflamed joints
• serum IgG1 levels are dramatically increased
• a greater proportion of T cells express late activation markers (CD44hi CD62Llo, CD45RBlo) than in transgene negative controls
• T cells expressing the transgenic TCR proliferate in response to antigen presenting cells expressing Class II MHC from a H2g7 locus in the absence of any antigen

cellular
• macrophage cells make up a large number of cells found in inflamed joints
• T cells expressing the transgenic TCR proliferate in response to antigen presenting cells expressing Class II MHC from a H2g7 locus in the absence of any antigen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rheumatoid arthritis DOID:7148 OMIM:180300
J:36815


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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory