Analysis Tools
immune system
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• macrophage cells make up a large number of cells found in inflamed joints
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• splenomegaly is often observed
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• clonal deletion is evident in the thymus of neonatal mice with reduced numbers of total cells and aberrant percentages of single-positive populations
• single-positive populations normalize by 4 weeks of age though total cell numbers are still reduced
• clonal deletion affects T cell populations in the periphery with a paucity of single-positive T cells in young mice and chronically reduced CD4+ population in adults
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• spleen and lymph node B cell numbers are increased 1.75-fold in mice suffering from arthritis
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• CD4+ T cells are virtually absent in the spleens of mice under 2 weeks of age
• CD4+ T cell numbers are reduced by 3.1-fold in the spleens of adult mice
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• CD8 +T cells numbers are reduced in mice under 3 weeks of age
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• neutrophils make up a large number of cells found in inflamed joints
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• serum IgG1 levels are dramatically increased
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• a greater proportion of T cells express late activation markers (CD44hi CD62Llo, CD45RBlo) than in transgene negative controls
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• T cells expressing the transgenic TCR proliferate in response to antigen presenting cells expressing Class II MHC from a H2g7 locus in the absence of any antigen
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• Background Sensitivity: transgenic T cells from mice on a NOD background have lower levels of T cell receptor expressed
• Background Sensitivity: transgenic T cells from mice on a NOD background have a severe reduction in response to its cognate antigen (RNAse peptide) presented by Ak than do transgenic T cells from a C57BL/6 background
• hybridomas created from these T cells respond normally to antigen suggesting a cell intrinsic anergy
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• Background Sensitivity: transgenic mice crossed to a NOD background develop rheumatoid arthritis
• distal paws become red and swollen
• all transgenic mice have significantly swollen ankles by 30 days of age with the degree of swelling symmetrical on either limb
• as mice age hyperextension of the ankle, valgus deviation of the knee and hyperpronation of the toes occur
• arthritis occurs in almost all joints with the exception of hip joints
• arthritis starts as fibrinoid material and a few cells are found in the articular cavity; edema sets in under the synovial lining, accompanied by neovascularithezation and some infiltration of inflammatory cells
• after a few weeks, disease is marked by extensive synovitis, affecting all areas of the joint with massive infiltration of inflammatory cells and beginnings of fibrosis
• after several months, the inflammation recedes leaving massive fibrosis, very little cartilage, and irregular shaped bone
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• occurs as part of arthritis disease process
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• immunoglobulin deposits occur along the peritubular basal membranes in the cortex and medulla
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• immunoglobulin deposits are detected in the glomeruli
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limbs/digits/tail
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• bones are eroded from arthritis with anarchic reconstruction occurring afterwards
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clinodactyly
(
J:36815
)
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• rheumatoid arthritis leads to hyperpronation of the toes
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• bones are eroded from arthritis with anarchic reconstruction occurring afterwards
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skeleton
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• Background Sensitivity: transgenic mice crossed to a NOD background develop rheumatoid arthritis
• distal paws become red and swollen
• all transgenic mice have significantly swollen ankles by 30 days of age with the degree of swelling symmetrical on either limb
• as mice age hyperextension of the ankle, valgus deviation of the knee and hyperpronation of the toes occur
• arthritis occurs in almost all joints with the exception of hip joints
• arthritis starts as fibrinoid material and a few cells are found in the articular cavity; edema sets in under the synovial lining, accompanied by neovascularithezation and some infiltration of inflammatory cells
• after a few weeks, disease is marked by extensive synovitis, affecting all areas of the joint with massive infiltration of inflammatory cells and beginnings of fibrosis
• after several months, the inflammation recedes leaving massive fibrosis, very little cartilage, and irregular shaped bone
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• occurs as part of arthritis disease process
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• bones are eroded from arthritis with anarchic reconstruction occurring afterwards
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• bones are eroded from arthritis with anarchic reconstruction occurring afterwards
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• intervertebral inflammation occurs sporadically in these mice
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• mobility is compromised due to arthritis
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renal/urinary system
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• immunoglobulin deposits occur along the peritubular basal membranes in the cortex and medulla
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• immunoglobulin deposits are detected in the glomeruli
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hematopoietic system
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• macrophage cells make up a large number of cells found in inflamed joints
|
|
• splenomegaly is often observed
|
|
• clonal deletion is evident in the thymus of neonatal mice with reduced numbers of total cells and aberrant percentages of single-positive populations
• single-positive populations normalize by 4 weeks of age though total cell numbers are still reduced
• clonal deletion affects T cell populations in the periphery with a paucity of single-positive T cells in young mice and chronically reduced CD4+ population in adults
|
|
• spleen and lymph node B cell numbers are increased 1.75-fold in mice suffering from arthritis
|
|
• CD4+ T cells are virtually absent in the spleens of mice under 2 weeks of age
• CD4+ T cell numbers are reduced by 3.1-fold in the spleens of adult mice
|
|
• CD8 +T cells numbers are reduced in mice under 3 weeks of age
|
|
• neutrophils make up a large number of cells found in inflamed joints
|
|
• serum IgG1 levels are dramatically increased
|
|
• a greater proportion of T cells express late activation markers (CD44hi CD62Llo, CD45RBlo) than in transgene negative controls
|
|
• T cells expressing the transgenic TCR proliferate in response to antigen presenting cells expressing Class II MHC from a H2g7 locus in the absence of any antigen
|
cellular
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• macrophage cells make up a large number of cells found in inflamed joints
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• T cells expressing the transgenic TCR proliferate in response to antigen presenting cells expressing Class II MHC from a H2g7 locus in the absence of any antigen
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growth/size/body
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• splenomegaly is often observed
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| rheumatoid arthritis | DOID:7148 |
OMIM:180300 |
J:36815 | |
