Phenotypes Associated with This Genotype

Genotype
MGI:3839859

• Allelic Composition: Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺; Trp53^tm3Tyj/Trp53⁺; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺; TgTn(sb-T2/Onc)68Dla/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

liver/biliary system

abnormal liver morphology ( J:147264 )

• preneoplastic nodules are first detected at about 160 days of age in males

• liver nodules in quadruple transgenic mice are larger and more numerous compared to triple transgenic mice that are wild-type at the Trp53 locus

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females