Phenotypes for Pten Tg(Gfap-cre)77.6Mvs MGI:3838843 MGI Mouse

abnormal neuron differentiation ( J:146630 )

• cultured adult neural stem cells maintain their ability to differentiate into neurons for a longer time compared to wild-type cells

abnormal neuronal precursor proliferation ( J:146630 )

• in culture, neurospheres formed by adult neural stem cells are generally larger and the stem cells' capacity for self renewal is prolonged compared to wild-type cells

abnormal response to CNS ischemic injury ( J:146630 )

• 7 days after induction of limited stroke in the sensorimotor cortex, mice have more neuroblasts in the peri-infarct cortex compared to controls

• however, there is no difference in the number of new cells present at 90 days after stroke induction

abnormal olfactory bulb morphology ( J:146630 )

• continuous increase in the weight and size of the olfactory bulb compared to controls starting at 2.5 months of age

• the granule cell layer volume is increased 2 fold at 3.5 months of age

• the increase in volume is due to an increase in the number of cells migrating from the subependymal zone to the olfactory bulb and a decrease in the number of apoptotic cells in the granule cell layer

abnormal postnatal subventricular zone morphology ( J:146630 )

• increase in the volume of the subependymal zone compared to controls

• increase in the number of proliferating cells and DCX positive neuroblasts

increased neuronal precursor cell number ( J:146630 )

• expansion of the adult neural stem cell and progenitor populations in the subependymal zone

abnormal response to novel odor ( J:146630 )

• habituate faster to a novel odorant compared to controls

• however, no difference in response is seen on the first exposure to a novel odorant

abnormal olfaction ( J:146630 )

• mice recover olfactory ability more quickly following exposure to dichlobenil compared to controls

neoplasm ( J:146630 , J:154673 )

N	• in contrast to other conditional null Pten genotypes no tumors are found in mice up to 2 years of age (J:146630) (J:154673)