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Phenotypes Associated with This Genotype
Genotype
MGI:3837711
Allelic
Composition		 Eef1a1tm1(Kras*)Arge/Eef1a1+
Igf1rtm2Arge/Igf1rtm2Arge
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1(Kras*)Arge mutation (0 available); any Eef1a1 mutation (60 available)
Igf1rtm2Arge mutation (1 available); any Igf1r mutation (88 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:146290 )
• median tumor free survival of lactating females is 101 days from the first parturition

neoplasm
increased mammary gland tumor incidence ( J:146290 )
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:146290 )
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition

integument
increased mammary gland tumor incidence ( J:146290 )
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory