Mouse Genome Informatics
cn
    Eef1a1tm1(Kras*)Arge/Eef1a1+
Waptm1(cre)Arge/Wap+

involves: 129S1/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• median tumor-free survival of lactating female mice is 9 days from the first parturition

tumorigenesis
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:146290