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Phenotypes Associated with This Genotype
Genotype
MGI:3837707
Allelic
Composition
Eef1a1tm1(Kras*)Arge/Eef1a1+
Waptm1(cre)Arge/Wap+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1(Kras*)Arge mutation (0 available); any Eef1a1 mutation (50 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass

integument
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass

mortality/aging
• median tumor-free survival of lactating female mice is 9 days from the first parturition

neoplasm
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:146290


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory