Analysis Tools
mortality/aging
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• by P25
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nervous system
| N |
• at P0, brain architecture is normal
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• neuroblast apoptosis in the subventricular zone is increased compared to in wild-type mice
• however, neuroblast proliferation is normal
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• neuroblasts fail to migrate properly to the olfactory bulb and accumulate in the subventricular zone and halfway through the rostral migratory stream unlike in wild-type mice
• neuroblasts fail to segregate from astrocytes unlike in wild-type mice
• neuroblasts transplanted into the subventricular zone of wild-type mice exhibit impaired migration unlike wild-type
• neuroblasts fail to undergo chain migration in culture unlike wild-type cells
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• mild at P15
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• neuroblasts fail to migrate properly to the olfactory bulb and accumulate in the subventricular zone and halfway through the rostral migratory stream unlike in wild-type mice
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• disorganized
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• disorganized
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• disorganized
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• neuroblasts fail to migrate properly to the olfactory bulb and accumulate in the subventricular zone and halfway through the rostral migratory stream unlike in wild-type mice
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• at P0 and P15
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• at P15, fewer cortical GABAergic interneurons are present compared to in wild-type mice
• at P15, fewer calbindin+ interneurons are present in cortical layers IV-VI compared to in wild-type mice
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• at P15, fewer cortical GABAergic interneurons are present compared to in wild-type mice
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cardiovascular system
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• between P3 and P7, retinal vasculature exhibits a 60% decrease in vascular sprouting compared to in wild-type mice with incomplete coverage at the retinal periphery
• at P18, intermediate and deep retinal vascular layers are poorly developed unlike in wild-type mice
• however, tip cells and pericytes in the developing retina are normal
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• the length of blood vessels in the brain cortex is decreased compared to in wild-type mice
• capillary outgrowth of P7 aortic rings treated with VEGF-A is impaired compared to in similarly treated wild-type aortic rings
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growth/size/body
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• beginning at P7
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weight loss
(
J:145672
)
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• after P7 to P8
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vision/eye
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• between P3 and P7, retinal vasculature exhibits a 60% decrease in vascular sprouting compared to in wild-type mice with incomplete coverage at the retinal periphery
• at P18, intermediate and deep retinal vascular layers are poorly developed unlike in wild-type mice
• however, tip cells and pericytes in the developing retina are normal
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cellular
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• neuroblast apoptosis in the subventricular zone is increased compared to in wild-type mice
• however, neuroblast proliferation is normal
|
|
• neuroblasts fail to migrate properly to the olfactory bulb and accumulate in the subventricular zone and halfway through the rostral migratory stream unlike in wild-type mice
• neuroblasts fail to segregate from astrocytes unlike in wild-type mice
• neuroblasts transplanted into the subventricular zone of wild-type mice exhibit impaired migration unlike wild-type
• neuroblasts fail to undergo chain migration in culture unlike wild-type cells
|
