Analysis Tools
mortality/aging
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• most die within the first 24 hours of birth
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• 70% of mice die before weaning age
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growth/size/body
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• mice that survive past weaning show mild growth retardation
• surviving mice are otherwise healthy
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hematopoietic system
| N |
• all hematopoietic cells present in near normal proportions in peripheral blood
• no spontaneous hematological disease over 1 year of observation
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• spleen cell colony formation after transplantation to irradiated hosts is normal after 8 days but severely reduced after 12 days
• competitive repopulation tests show a moderate under-representation of mutant cells at 4 weeks
• competitive repopulation tests show a significant under-representation of mutant cells at 3 months
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• somewhat elevated in the circulation but not in bone marrow
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• significantly reduced, particularly in the liver
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• significantly reduced, particularly in the liver
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• normal numbers of multipotent progenitor cells derived from short-term repopulating stem cells
• granulocyte/macrophage progenitors are reduced
• megakaryocyte/erythrocyte progenitors are increased in number
• significantly reduced number of common lymphoid progenitors
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• 30% reduction in long-term repopulating hematopoietic stem cells
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• increased numbers of short-term repopulating stem cells
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immune system
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• somewhat elevated in the circulation but not in bone marrow
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• significantly reduced, particularly in the liver
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• significantly reduced, particularly in the liver
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