Phenotypes Associated with This Genotype

Genotype
MGI:3834656

• Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa; Tcrb^Ln3Jae/Tcrb⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal double-negative T cell morphology ( J:143006 )

• there is a severe reduction in the percentage of thymocytes at the DN1-3 stages

increased double-positive T cell number ( J:143006 )

• double-positive T cells make up 95% of the cells in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• CD4⁺ T cells make up about 3% of the splenocyte population

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are absent in these mice

hematopoietic system

abnormal double-negative T cell morphology ( J:143006 )

• there is a severe reduction in the percentage of thymocytes at the DN1-3 stages

increased double-positive T cell number ( J:143006 )

• double-positive T cells make up 95% of the cells in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• CD4⁺ T cells make up about 3% of the splenocyte population

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are absent in these mice