Phenotypes Associated with This Genotype

Genotype
MGI:3834177

• Allelic Composition: Slc4a1^tm1Dmb/Slc4a1^tm1Dmb
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal bone marrow cell number ( J:145243 )

• increase in the percentage of Ter119 positive erythroid cells in the bone marrow

abnormal erythrocyte morphology ( J:145243 )

• cells are smaller compared to controls

poikilocytosis ( J:145243 )

• contain a higher percentage of spherocytes and stomatocytes

• almost half of all red blood cells are abnormally shaped compared to less than 5% in wild-type controls

stomatocytosis ( J:145243 )

• contain a higher percentage of spherocytes and stomatocytes

reticulocytosis ( J:145243 )

• significantly higher percentage of reticulocytes in the peripheral blood

abnormal splenic cell ratio ( J:145243 )

• increase in the percentage of Ter119 positive erythroid cells in the spleen

increased erythrocyte osmotic fragility ( J:145243 )

• increase in the osmotic fragility of erythrocytes

immune system

abnormal splenic cell ratio ( J:145243 )

• increase in the percentage of Ter119 positive erythroid cells in the spleen