Slc4a1^tm1Dmb
Targeted Allele Detail

Summary

• Symbol: Slc4a1^tm1Dmb
• Name: solute carrier family 4 (anion exchanger), member 1; targeted mutation 1, David M Bodine
• MGI ID: MGI:3834176
• Synonyms: ld
• Gene: Slc4a1 Location: Chr11:102239646-102256107 bp, - strand Genetic Position: Chr11, 66.29 cM, cytoband D
• Alliance: Slc4a1^tm1Dmb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145243
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 33 bp region of exon 7, encoding the 11 amino acids of the beta-hairpin loop, was replaced with sequence encoding 2 glycine residues and a floxed neo cassette was inserted into intron 4 via homologous recombination. The neo cassette was then removed via Cre mediated recombination leaving a single loxP site in intron 4. (J:145243)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a1 Mutation: 54 strains or lines available

References

• Original: J:145243 Stefanovic M, et al., An 11-amino acid beta-hairpin loop in the cytoplasmic domain of band 3 is responsible for ankyrin binding in mouse erythrocytes. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13972-7
• All: 1 reference(s)