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Phenotypes Associated with This Genotype
Genotype
MGI:3831430
Allelic
Composition
Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Brn mutation (3 available); any Brca2 mutation (76 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53tm1Brn mutation (7 available); any Trp53 mutation (156 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

neoplasm
• mice develop tumors with a short median latency period of 181 days
• tumors exhibit expansive growth pattern, a high nuclear grade, and a high mitotic index
• mice develop skin carcinomas

integument
• mice develop skin carcinomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
OMIM:600048
OMIM:605365
J:73028


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/17/2017
MGI 6.10
The Jackson Laboratory