Analysis Tools
neoplasm
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• carcinoma develops in the prostate at different rates depending on age of mouse when tamoxifen administration occurs
• when tamoxifen is given to mice at two weeks of age, overt neoplasia and microinvasive carcinoma are evident 10 to 12 weeks later in one-third of mice
• when tamoxifen is given to mice 6 weeks of age, a more gradual progression to carcinoma occurs with overtly malignant lesions not present until 1 year of age
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• when tamoxifen is given to mice at 2 weeks of age, hyperplastic regions as well as low grade PIN lesions and an increased number of apoptotic cells are evident 4 to 6 weeks later
• by 10-12 weeks post injection, all mice display increased proliferation of the prostate epithelium and high grade PIN lesions with a third of the mice having microinvasive carcinomas
• when tamoxifen is given to mice at 6 weeks of age, early hyperplastic lesions and increased proliferation rates of the prostate epithelium are evident 4 weeks later
• about half the mice exhibit advanced PIN lesions at 16-20 weeks after tamoxifen administration at 6 weeks of age
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endocrine/exocrine glands
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• carcinoma develops in the prostate at different rates depending on age of mouse when tamoxifen administration occurs
• when tamoxifen is given to mice at two weeks of age, overt neoplasia and microinvasive carcinoma are evident 10 to 12 weeks later in one-third of mice
• when tamoxifen is given to mice 6 weeks of age, a more gradual progression to carcinoma occurs with overtly malignant lesions not present until 1 year of age
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• when tamoxifen is given to mice at 2 weeks of age, hyperplastic regions as well as low grade PIN lesions and an increased number of apoptotic cells are evident 4 to 6 weeks later
• by 10-12 weeks post injection, all mice display increased proliferation of the prostate epithelium and high grade PIN lesions with a third of the mice having microinvasive carcinomas
• when tamoxifen is given to mice at 6 weeks of age, early hyperplastic lesions and increased proliferation rates of the prostate epithelium are evident 4 weeks later
• about half the mice exhibit advanced PIN lesions at 16-20 weeks after tamoxifen administration at 6 weeks of age
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reproductive system
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• carcinoma develops in the prostate at different rates depending on age of mouse when tamoxifen administration occurs
• when tamoxifen is given to mice at two weeks of age, overt neoplasia and microinvasive carcinoma are evident 10 to 12 weeks later in one-third of mice
• when tamoxifen is given to mice 6 weeks of age, a more gradual progression to carcinoma occurs with overtly malignant lesions not present until 1 year of age
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• when tamoxifen is given to mice at 2 weeks of age, hyperplastic regions as well as low grade PIN lesions and an increased number of apoptotic cells are evident 4 to 6 weeks later
• by 10-12 weeks post injection, all mice display increased proliferation of the prostate epithelium and high grade PIN lesions with a third of the mice having microinvasive carcinomas
• when tamoxifen is given to mice at 6 weeks of age, early hyperplastic lesions and increased proliferation rates of the prostate epithelium are evident 4 weeks later
• about half the mice exhibit advanced PIN lesions at 16-20 weeks after tamoxifen administration at 6 weeks of age
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