mortality/aging
• tamoxifen administration leads to death of the mouse within 90 days from small intestine carcinoma
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neoplasm
• two days after tamoxifen administration, there is a marked expansion of YFP+ cells within the crypts of the small intestine
• cultures of these cells yields four times as many, and much larger, clonogenic colonies
• ten days after tamoxifen administration, small intestine crypts are markedly disorganized with contiguous streams of YFP+ flowing out to the villi and forming a carpet of hyperplastic and grossly dysplastic cells
• sixty days after tamoxifen administration, the small intestine is twice the normal width and has a thickened, rugous appearance
• high-grade intraepithelial neoplasia and crypt adenoma formation is observed at the microscopic level sixty days after tamoxifen administration
• all mice die from the intestinal adenocarcinoma within 90 days of tamoxifen administration
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digestive/alimentary system
• two days after tamoxifen administration, there is a marked expansion of YFP+ cells within the crypts of the small intestine
• cultures of these cells yields four times as many, and much larger, clonogenic colonies
• ten days after tamoxifen administration, small intestine crypts are markedly disorganized with contiguous streams of YFP+ flowing out to the villi and forming a carpet of hyperplastic and grossly dysplastic cells
• sixty days after tamoxifen administration, the small intestine is twice the normal width and has a thickened, rugous appearance
• high-grade intraepithelial neoplasia and crypt adenoma formation is observed at the microscopic level sixty days after tamoxifen administration
• all mice die from the intestinal adenocarcinoma within 90 days of tamoxifen administration
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