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Phenotypes Associated with This Genotype
Genotype
MGI:3830516
Allelic
Composition		 Smarca4tm1Tich/Smarca4+
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1Tich mutation (0 available); any Smarca4 mutation (110 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:144072 )
• total thymocyte numbers are slightly reduced compared to in wild-type mice
decreased double-negative T cell number ( J:144072 )
• DN4 cells are completely missing
decreased single-positive T cell number ( J:144072 )
• immature single positive cells are lost

hematopoietic system
decreased thymocyte number ( J:144072 )
• total thymocyte numbers are slightly reduced compared to in wild-type mice
decreased double-negative T cell number ( J:144072 )
• DN4 cells are completely missing
decreased single-positive T cell number ( J:144072 )
• immature single positive cells are lost

endocrine/exocrine glands
decreased thymocyte number ( J:144072 )
• total thymocyte numbers are slightly reduced compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory