Phenotypes Associated with This Genotype

Genotype
MGI:3830512

• Allelic Composition: Smarca4^tm1.2Pcn/Smarca4^tm1Tich; Tg(Lck-cre)1Cwi/0; Tg(LCKprBCL2L1)12Sjk/0
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell morphology ( J:144072 )

• unlike in Smarca4^tm1Grc/Smarca4^tm1Grc Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population is not observed

• 25% of the post-DN3 population is composed of CD4-DN4 cells compared to 9% in Smarca4^tm1Grc/Smarca4^tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice

• 39% of the post-DN3 population is composed of CD4+DN4 cells compared to 52% in Smarca4^tm1Grc/Smarca4^tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice

• mice exhibit two CD4+ populations with different levels of CD4 expression

increased thymocyte number ( J:144072 )

increased double-negative T cell number ( J:144072 )

decreased double-positive T cell number ( J:144072 )

hematopoietic system

abnormal T cell morphology ( J:144072 )

• unlike in Smarca4^tm1Grc/Smarca4^tm1Grc Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population is not observed

• 25% of the post-DN3 population is composed of CD4-DN4 cells compared to 9% in Smarca4^tm1Grc/Smarca4^tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice

• 39% of the post-DN3 population is composed of CD4+DN4 cells compared to 52% in Smarca4^tm1Grc/Smarca4^tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice

• mice exhibit two CD4+ populations with different levels of CD4 expression

increased thymocyte number ( J:144072 )

increased double-negative T cell number ( J:144072 )

decreased double-positive T cell number ( J:144072 )

endocrine/exocrine glands

increased thymocyte number ( J:144072 )