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Phenotypes Associated with This Genotype
Genotype
MGI:3830511
Allelic
Composition		 Smarca4tm1.2Pcn/Smarca4tm1Tich
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (109 available)
Smarca4tm1Tich mutation (0 available); any Smarca4 mutation (109 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell morphology ( J:144072 )
• 38% of the post-DN3 population is composed of CD4+CD8- cells compared to 14% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice
• unlike in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population analogous to immature single positive cells is not observed
decreased thymocyte number ( J:144072 )
• thymocyte numbers are reduced 13-fold compared to in wild-type mice
decreased double-negative T cell number ( J:144072 )
• post-DN3 T cells are reduced compared to in wild-type mice
• however, DN3 cellularity is normal

hematopoietic system
abnormal T cell morphology ( J:144072 )
• 38% of the post-DN3 population is composed of CD4+CD8- cells compared to 14% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice
• unlike in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population analogous to immature single positive cells is not observed
decreased thymocyte number ( J:144072 )
• thymocyte numbers are reduced 13-fold compared to in wild-type mice
decreased double-negative T cell number ( J:144072 )
• post-DN3 T cells are reduced compared to in wild-type mice
• however, DN3 cellularity is normal

endocrine/exocrine glands
decreased thymocyte number ( J:144072 )
• thymocyte numbers are reduced 13-fold compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory