Phenotypes for Ctcf Rag2 Tg(Lck-cre)1Cwi MGI:3829023 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ctcf^tm2Gal/Ctcf^tm2Gal Rag2^tm1Fwa/Rag2^tm1Fwa Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctcf^tm2Gal mutation (0 available); any Ctcf mutation (78 available)
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-positive T cell number ( J:143271 )

• despite increased double positive T cell production stimulated by anti-CD3epsilon treatment, mice produce fewer double positive T cells compared to similarly treated Rag2^tm1Fwa homozygotes

hematopoietic system

decreased double-positive T cell number ( J:143271 )

• despite increased double positive T cell production stimulated by anti-CD3epsilon treatment, mice produce fewer double positive T cells compared to similarly treated Rag2^tm1Fwa homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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