Phenotypes Associated with This Genotype

Genotype
MGI:3821936

• Allelic Composition: Gt(ROSA)26Sor^{tm1(MYC/ERT2)Gev}/Gt(ROSA)26Sor^{tm1(MYC/ERT2)Gev}; Kras^tm4Tyj/Kras^tm4Tyj
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:142030 )

• following intranasal treatment with adenovirus cre only, mice exhibit hyperplastic and dysplastic bronchiolar lesions unlike similarly treated wild-type mice but similar to in cre-activated Kras^tm4Tyj homozygotes

• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen, mice develop large and numerous papillary adenomas that are poorly differentiated and grow in small tumor clusters with individual cells embedded within desmoplastic stroma

increased lung adenoma incidence ( J:142030 )

• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen

respiratory system

increased lung tumor incidence ( J:142030 )

• following intranasal treatment with adenovirus cre only, mice exhibit hyperplastic and dysplastic bronchiolar lesions unlike similarly treated wild-type mice but similar to in cre-activated Kras^tm4Tyj homozygotes

• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen, mice develop large and numerous papillary adenomas that are poorly differentiated and grow in small tumor clusters with individual cells embedded within desmoplastic stroma

increased lung adenoma incidence ( J:142030 )

• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen