Gt(ROSA)26Sor^{tm1(MYC/ERT2)Gev}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(MYC/ERT2)Gev}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Gerard Evan
• MGI ID: MGI:3821930
• Synonyms: R26^lsl-MER
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(MYC/ERT2)Gev} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142030
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Mutation details: A fused human MYC and ESR1 (ERT2) sequence, preceded by a floxed neo cassette with a triple polyadenylation sequence and followed by an IRES-EGFP, was inserted into the ROSA locus. Expression of the fusion product can only be achieved through cre mediated removal of the neo cassette along with its polyadenlylation sequences. (J:142030)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1046 strains or lines available

References

• Original: J:142030 Murphy DJ, et al., Distinct thresholds govern Myc's biological output in vivo. Cancer Cell. 2008 Dec 9;14(6):447-57
• All: 4 reference(s)