Analysis Tools
behavior/neurological
| N |
• despite locomotor deficits, mice exhibit normal balance, coordination and anxiety levels
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• mice exhibit reduced learning of active avoidance behaviors in a T-maze test compared to wild-type mice
• in a T-maze mice exhibit longer avoidance time than wild-type mice
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• mice perform worse than wild-type mice in a passive avoidance T-maze test and exhibit increased time to make the incorrect response compared to wild-type mice
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• mice fail to exhibit an increase in locomotor activity when exposed to a novel environment
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• when exposed to a male intruder, male mice initiate fewer attacks and exhibit increased latency to attack compared to wild-type mice
• however, serotonine and dopamine levels are normal
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• mice exhibit reduced grip strength compared to wild-type mice
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• mice exhibit reduced locomotion in new and familiar environments compared to wild-type mice
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nervous system
| N |
• mice exhibit normal brain morphology and levels of serotonine and dopamine are normal
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• neurons have smaller growth cones with reduced widths compare to wild-type growth cones and they extend along the shaft unlike growth cones
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• young and old cultured neurons have fewer, shorter neurites than wild-type neurons
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reproductive system
| N |
• mice are fertile and male mice exhibit normal testes morphology
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