Phenotypes for Gata1 Gata2 MGI:3820403 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gata1^tm4Sho/Y Gata2^tm2Sho/Gata2^tm2Sho
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm4Sho mutation (0 available); any Gata1 mutation (46 available)
Gata2^tm2Sho mutation (0 available); any Gata2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:77724 )

• mice begin to die at late E10.5

hematopoietic system

hematopoietic system phenotype ( J:77724 )

N	• despite disruptions in erythropoiesis and megakaryopoiesis, granulocytes and macrophages form normally

abnormal erythropoiesis ( J:77724 )

• erythropoeisis is arrested in maturation at a precursor stage

abnormal megakaryocyte progenitor cell morphology ( J:77724 )

• no megakaryocyte colonies can be generated from yolk sac cells unlike when wild-type cells are cultured

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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