Phenotypes Associated with This Genotype

Genotype
MGI:3819935

• Allelic Composition: Bnip3l^tm1Ney/Bnip3l^tm1Ney
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:141545 )

spleen hyperplasia ( J:141545 )

• the numbers of Ter119+ GR1+ and Mac1+ cells are increased in the spleen compared to in wild-type mice

abnormal definitive hematopoiesis ( J:141545 )

• mice exhibit hyperplasia of erythroid-myeloid cells unlike in wild-type mice

anemia ( J:141545 )

abnormal erythrocyte morphology ( J:141545 )

• half of circulating erythrocytes contain mitochondria unlike in wild-type erythrocytes

• erythrocytes that develop from bone marrow transplanted into wild-type recipients exhibits increased mitochondria content compared to in wild-type cells

• however, erythrocytes clear their ribosomes normally

decreased erythrocyte cell number ( J:141545 )

decreased hematocrit ( J:141545 )

poikilocytosis ( J:141545 )

polychromatophilia ( J:141545 )

spherocytosis ( J:141545 )

reticulocytosis ( J:141545 )

cellular

abnormal mitophagy ( J:141545 )

• cultured reticulocytes exhibit abnormal autophagy of mitochrondria with mitochondria associated with the outer membrane of the autophagosome and undegraded autophagosome content unlike in wild-type reticulocytes

immune system

enlarged spleen ( J:141545 )

spleen hyperplasia ( J:141545 )

• the numbers of Ter119+ GR1+ and Mac1+ cells are increased in the spleen compared to in wild-type mice

growth/size/body

enlarged spleen ( J:141545 )

spleen hyperplasia ( J:141545 )

• the numbers of Ter119+ GR1+ and Mac1+ cells are increased in the spleen compared to in wild-type mice

homeostasis/metabolism

abnormal mitophagy ( J:141545 )

• cultured reticulocytes exhibit abnormal autophagy of mitochrondria with mitochondria associated with the outer membrane of the autophagosome and undegraded autophagosome content unlike in wild-type reticulocytes