Phenotypes Associated with This Genotype

Genotype
MGI:3819858

• Allelic Composition: Foxq1^sa/Foxq1⁺; Sox4^M91Ark/Del(13)36H
• Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:101156 )

• almost all mice die before birth, with a significant deviation from expected Mendelian frequencies first noted at E14.5

cardiovascular system

abnormal aortic arch morphology ( J:101156 )

• smaller than the pulmonary artery

abnormal cardiovascular development ( J:101156 )

• circulatory failure

abnormal heart morphology ( J:101156 )

abnormal heart development ( J:101156 )

• common atrioventricular junction

double outlet right ventricle ( J:101156 )

• the aorta and pulmonary artery both originate from the right ventricle

abnormal mitral valve morphology ( J:101156 )

• the mitral valve of E14.5 embryos is dysplastic

ostium primum atrial septal defect ( J:101156 )

• a primum atrial septal defect is seen at the ventral margin of the primary atrial septum in E14.5 embryos

ventricular septal defect ( J:101156 )

• a large ventricular septum defect connects the left and right ventricles

renal/urinary system

abnormal kidney development ( J:101156 )

• kidneys of E14.5 embryos are hypoplastic and occasionally positioned abnormally

renal hypoplasia ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )