Phenotypes Associated with This Genotype

Genotype
MGI:3818605

• Allelic Composition: Atg5^tm1Myok/Atg5^tm1Myok; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal Paneth cell morphology ( J:141419 )

• aberrant, disorganized granules as well as decreased granule numbers are observed in these mice

• virtually all Paneth cells have lysozyme localized throughout the cell instead of being discretely packaged within vesicles

• Paneth cells also have degenerating mitochondria, loss of granules and the frequent absence of apical microvilli

• adjacent crypt lumen often contains intact Paneth granules and cytoplasm, which is a phenomenon not observed in wild-type controls

homeostasis/metabolism

impaired autophagy ( J:141419 )

• autophagy by the ileal epithelium is severely reduced in these mice

cellular

impaired autophagy ( J:141419 )

• autophagy by the ileal epithelium is severely reduced in these mice

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:141419 )

• aberrant, disorganized granules as well as decreased granule numbers are observed in these mice

• virtually all Paneth cells have lysozyme localized throughout the cell instead of being discretely packaged within vesicles

• Paneth cells also have degenerating mitochondria, loss of granules and the frequent absence of apical microvilli

• adjacent crypt lumen often contains intact Paneth granules and cytoplasm, which is a phenomenon not observed in wild-type controls