Phenotypes Associated with This Genotype

Genotype
MGI:3818073

• Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm2Mrt; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129 * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:109474 )

N • phenotype is stated to be identical to that of Fgf8^tm1.3Mrt/ Fgf8^tm1.4Mrt; Nkx2-5^tm1(cre)Rjs/ Nkx2-5⁺ mutants; however no data are presented

embryo

abnormal pharyngeal arch morphology ( J:109474 )

• at E9.5 cell proliferation in pharyngeal endoderm is reduced with cell mitotic indices decreased by 60% relative to controls

abnormal pharyngeal arch mesenchyme morphology ( J:109474 )

• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5

abnormal splanchnic mesoderm morphology ( J:109474 )

• thinning of splanchnic mesoderm (SM) layers

• at E9.5 cell proliferation in SM is reduced with cell mitotic indices decreased by 50% relative to controls

• excessive cell death is detected from E8.5-9.5 in SM immediately distal to emerging outflow tract and in endoderm adjacent to the SM

abnormal neural crest cell morphology ( J:109474 )

• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5, as well as in presumptive cardiac neural crest cells in close proximity to outflow tract

cardiovascular system

abnormal heart morphology ( J:109474 )

• phenotype is stated to be identical to that of Fgf8^tm1.3Mrt/ Fgf8^tm1.4Mrt; Nkx2-5^tm1(cre)Rjs/ Nkx2-5⁺ mutants; however no data are presented

abnormal heart development ( J:109474 )

• anterior heart field (AHF) cells are mildly reduced compared to controls, resulting in thinning of splanchnic mesoderm (SM) layers

• at E9.5 cell proliferation in SM is reduced with cell mitotic indices decreased by 50% relative to controls; excessive cell death is detected from E8.5-9.5 in SM immediately distal to emerging outflow tract and in endoderm adjacent to the SM, with excessive cell death expanding into ventral pharyngeal endoderm by E9.5 but not in SM at this stage

craniofacial

abnormal pharyngeal arch morphology ( J:109474 )

• at E9.5 cell proliferation in pharyngeal endoderm is reduced with cell mitotic indices decreased by 60% relative to controls

abnormal pharyngeal arch mesenchyme morphology ( J:109474 )

• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5

cellular

decreased mitotic index ( J:109474 )

• indices are reduced by 50% and 60% in splanchnic mesoderm and pharyngeal endoderm at E9.5

nervous system

abnormal neural crest cell morphology ( J:109474 )

• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5, as well as in presumptive cardiac neural crest cells in close proximity to outflow tract

growth/size/body

abnormal pharyngeal arch mesenchyme morphology ( J:109474 )

• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5