Phenotypes Associated with This Genotype

Genotype
MGI:3818072

• Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:109474 )

• mutant embryos are present at expected ratio up to E9.5, but a marked reduction is observed at later times with no surviving mutants by E10.5

embryo

pharyngeal arch hypoplasia ( J:109474 )

• arches are hypoplastic at E9.5

cardiovascular system

absent cardiac outflow tract ( J:109474 )

• presumptive outflow tract (OT) is almost completely absent at E9.5; only a small segment of myocardium joins left ventricle to aortic sac

abnormal heart tube morphology ( J:109474 )

• at E9.5, heart tube is severely truncated

dilated heart atrium ( J:109474 )

• both atria are slightly dilated at E9.5

dilated heart left ventricle ( J:109474 )

• slightly at E9.5

absent heart right ventricle ( J:109474 )

• almost completely absent at E9.5

craniofacial

pharyngeal arch hypoplasia ( J:109474 )

• arches are hypoplastic at E9.5