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Phenotypes Associated with This Genotype
Genotype
MGI:3817454
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• after 5 months
• after 5 months

mortality/aging
• mice exhibit increased mortality after 6 months and no mice survives beyond 22 months

reproductive system
• mice exhibit hemorrhage into the ovarian follicles
• female mice mated to wild-type mice exhibit reduced litter size compared to wild-type female mice

hematopoietic system
• after 5 months
• beyond 5 months of age, mice exhibit immature and maturing mononuclear cells in the peripheral blood unlike wild-type mice
• increased in the spleen and bone marrow
• after 5 months, mice exhibit extramedullary hematopoiesis in the liver and spleen
• after 5 months, mice exhibit increased erythropoiesis in the spleen
• at 2 to 5 months of age, mice exhibit mild anemia that becomes severe beyond 5 months of age
• in mice older than 5 months
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• in the spleens of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• in mice older than 5 months
• at 2 to 5 months of age, mice exhibit a progressive loss of platelets that becomes severe beyond 5 months of age
• at 2 to 5 months of age, mice exhibit mild leukopenia
• at 2 to 5 months of age
• at 2 to 5 months of age
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• in the spleen of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• beyond 5 months of age
• spleens mice with symptoms of chronic myelomonocytic leukemia (CMML)
• 12% of mice develop acute myeloid leukemia with a rapid increase in white blood cell count between 12 and 22 months
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• in the bone marrow and spleen

endocrine/exocrine glands
• mice exhibit hemorrhage into the ovarian follicles

liver/biliary system
• after 5 months

neoplasm
• mice exhibit chronic myelomonocytic leukemia (CMML) symptoms
• 12% of mice develop acute myeloid leukemia with a rapid increase in white blood cell count between 12 and 22 months
• mice with acute myeloid leukemia (AML) also develop myeloid sarcomas in spleens and livers

skeleton
• sick mice exhibit bone marrow with reticulin fibrosis and increased apoptosis compared to wild type mice
• hematopoietic stem cell populations are expanded in the bone marrow compared to in wild-type mice
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML) exhibits an increase in T cells and a decreased in erythrocytes and B cells compared to in wild-type mice
• sick mice exhibit bone marrow with reticulin fibrosis

respiratory system
• in mice older than 5 months

cardiovascular system
• mice exhibit hemorrhage into the ovarian follicles

behavior/neurological
• in mice older than 5 months

immune system
• beyond 5 months of age, mice exhibit immature and maturing mononuclear cells in the peripheral blood unlike wild-type mice
• after 5 months
• at 2 to 5 months of age, mice exhibit mild leukopenia
• at 2 to 5 months of age
• at 2 to 5 months of age
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• in the spleen of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• beyond 5 months of age
• spleens mice with symptoms of chronic myelomonocytic leukemia (CMML)
• 12% of mice develop acute myeloid leukemia with a rapid increase in white blood cell count between 12 and 22 months
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)

integument
• in mice older than 5 months

cellular
• beyond 5 months of age, mice exhibit immature and maturing mononuclear cells in the peripheral blood unlike wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:141004


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/13/2022
MGI 6.21
The Jackson Laboratory