Phenotypes Associated with This Genotype

Genotype
MGI:3815438

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Fabp4^tm1Brsp/Fabp4^tm1Brsp; Fabp5^tm1Hota/Fabp5^tm1Hota
• Genetic Background: B6.Cg-Fabp4^tm1Brsp Fabp5^tm1Hota Apoe^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:102223 )

N • mice fed a high fat diet exhibit a 100% survival rate at 1 year compared to a 33% survival for Apoe^tm1Unc homozygotes

homeostasis/metabolism

decreased circulating glucose level ( J:102223 )

• fasting serum glucose levels are reduced 48% in female mice compared to Apoe^tm1Unc homozygotes

• however, serum glucose levels in male mice is the same as in controls

decreased circulating cholesterol level ( J:102223 )

• fasting serum cholesterol levels are 18% lower in male mice and 29% lower in female mice compared to in Apoe^tm1Unc homozygotes

• however, serum cholesterol levels in female mice are the same as in controls

decreased circulating triglyceride level ( J:102223 )

• fasting serum triglyceride levels are 32% lower in male mice and 42% lower in female mice compared to in Apoe^tm1Unc homozygotes

• however, serum triglyceride levels in female mice are the same as in controls

improved glucose tolerance ( J:102223 )

• compared to Apoe^tm1Unc homozygotes

increased insulin sensitivity ( J:102223 )

• compared to Apoe^tm1Unc homozygotes

cardiovascular system

decreased susceptibility to atherosclerosis ( J:102223 )

• male mice exhibit a 53% reduction in mean atherosclerotic lesion and a 45% reduction in mean lesion are of the en face aorta compared to Apoe^tm1Unc homozygotes

• female mice exhibit a 37% reduction in mean atherosclerotic lesion and a 37% reduction in mean lesion are of the en face aorta compared to Apoe^tm1Unc homozygotes

• when fed a high fat diet, male mice exhibit a 26% reduction in atherosclerosis of the proximal aorta with a 78% reduction in the en face aorta lesion compared to in Apoe^tm1Unc homozygotes

growth/size/body

decreased body weight ( J:102223 )

• body weight of male mice is 10% lower than in Apoe^tm1Unc homozygotes

• however, female mice weigh the same as controls