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Phenotypes Associated with This Genotype
Genotype
MGI:3815142
Allelic
Composition
Cdkn2atm1Rdp/Cdkn2a+
X/Tg(Tyr-HRAS)60Lc
Genetic
Background
involves: 129/Sv * C57BL/6J * CBA/J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (5 available); any Cdkn2a mutation (26 available)
Tg(Tyr-HRAS)60Lc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• following exposure to UVA and UVB, 2 of 46 mice exhibit uveal melanoma (J:140820)
• following exposure to UVA and UVB, 2 of 46 mice exhibit uveal melanoma (J:140820)
• following exposure to UVA and UVB, 2 of 46 mice exhibit uveal melanoma (J:140820)
• following exposure to UVA and UVB, 2 of 46 mice exhibit uveal melanoma (J:140820)

vision/eye
• following exposure to UVA and UVB, only one mouse developed cataracts unlike Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(Tyr-HRAS)60Lc mice (J:140820)
• following exposure to UVA and UVB, only one mouse developed cataracts unlike Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(Tyr-HRAS)60Lc mice (J:140820)

Mouse Models of Human Disease
OMIM ID Ref(s)
Melanoma, Uveal 155720 J:140820


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory