Phenotypes for Kit Ly6a MGI:3815027 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Kit^W-v/Kit^W-v Ly6a^tm1Pmf/Ly6a^tm1Pmf
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-v mutation (9 available); any Kit mutation (175 available)
Ly6a^tm1Pmf mutation (0 available); any Ly6a mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:81387 )

• there is an 84% reduction in the number of compound homozygotes born compared to the number expected from Mendelian frequencies

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:81387 )

• E14 embryos have dramatically reduced CFU-Cs

anemia ( J:81387 )

• E14 embryos are very anemic

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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