Ly6a^tm1Pmf
Targeted Allele Detail

Summary

• Symbol: Ly6a^tm1Pmf
• Name: lymphocyte antigen 6 family member A; targeted mutation 1, Patrick M Flood
• MGI ID: MGI:2449938
• Synonyms: Ly-6A-, Sca-1-
• Gene: Ly6a Location: Chr15:74866726-74869880 bp, - strand Genetic Position: Chr15, 34.29 cM
• Alliance: Ly6a^tm1Pmf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42594
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 1-3 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by flow cytometric analysis of splenocytes from homozygous mutant animals. (J:42594)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ly6a Mutation: 20 strains or lines available

References

• Original: J:42594 Stanford WL, et al., Altered proliferative response by T lymphocytes of Ly-6A (Sca-1) null mice. J Exp Med. 1997 Aug 29;186(5):705-17
• All: 19 reference(s)