renal/urinary system
• hypoplasia is more severe than in mice with 4 mutant alleles
|
• kidneys, when present, are in a more caudal and ventral location
|
single kidney
(
J:88686
)
• occasionally seen
• more frequent than in mice with 4 mutant alleles
|
• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme
|