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Phenotypes Associated with This Genotype
Genotype
MGI:3814579
Allelic
Composition
Kmt2atm1Saam/Kmt2a+
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Saam mutation (0 available); any Kmt2a mutation (84 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• following pIpC treatment 14 of 22 mice developed acute leukemia
• median latency for leukemia development was 131 days
• infiltration of the bone marrow, spleen and liver with immature hematopoietic cells is seen in moribund mice
• mice may develop either acute myeloid leukemia or acute lymphoblastic leukemia
• gene expression profiles in mice with acute lymphoblastic leukemia recapitulate gene expression profiles seen in human acute lymphoid leukemia


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory