Phenotypes for Ednrb Gt(ROSA)26Sor H2az2 MGI:3814191 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ednrb^tm1Nrd/Ednrb^tm1Nrd Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^tm1Nrd mutation (1 available); any Ednrb mutation (107 available)
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (24 available); any Gt(ROSA)26Sor mutation (1062 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:140320 )

• mice die 5 weeks after birth

growth/size/body

slow postnatal weight gain ( J:140320 )

• after P25

distended abdomen ( J:140320 )

digestive/alimentary system

aganglionic megacolon ( J:140320 )

pigmentation

white spotting ( J:140320 )

• mice lack coat pigment in the trunk

embryo

abnormal enteric neural crest cell migration ( J:140320 )

• enteric neural crest cells fail to reach the anus

integument

white spotting ( J:140320 )

• mice lack coat pigment in the trunk

cellular

abnormal enteric neural crest cell migration ( J:140320 )

• enteric neural crest cells fail to reach the anus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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