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Phenotypes Associated with This Genotype
Genotype
MGI:3813633
Allelic
Composition
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (25 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• impaired survival is seen beginning around 5 months of age

reproductive system
• hyperplasia progresses to carcinoma by 1 month of age with invasion into the myometrium detected by 3 months of age
• by P10, luminal and glandular epithelial hyperplasia are seen

neoplasm
• hyperplasia progresses to carcinoma by 1 month of age with invasion into the myometrium detected by 3 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Endometrial Cancer 608089 J:139053


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory