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Phenotypes Associated with This Genotype
Genotype
MGI:3812133
Allelic
Composition
Dsg4hage/Dsg4hage
Faslpr/Faslpr
X/Yaa
Genetic
Background
EOD-Dsg4hage
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg4hage mutation (0 available); any Dsg4 mutation (19 available)
Faslpr mutation (24 available); any Fas mutation (47 available)
Yaa mutation (10 available); any Yaa mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the mean life span of these male mice is 99 days, which is significantly longer than the 88 day mean lifespan that males from this strain normally live (J:140028)
• the mean life span of these male mice is 99 days, which is significantly longer than the 88 day mean lifespan that males from this strain normally live (J:140028)

growth/size/body
• mice are generally smaller than controls (J:140028)
• mice are generally smaller than controls (J:140028)

immune system
• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls (J:140028)
• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls (J:140028)
• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice (J:140028)
• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice (J:140028)

hematopoietic system
• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls (J:140028)
• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls (J:140028)
• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice (J:140028)
• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice (J:140028)

integument
• pups have scanty growth of short hair on the head and back (J:140028)
• pups have scanty growth of short hair on the head and back (J:140028)
• the number of hair follicles in a given patch of skin appears to be higher than controls but counting is difficult because of the unusual orientation of the follicles (J:140028)
• the number of hair follicles in a given patch of skin appears to be higher than controls but counting is difficult because of the unusual orientation of the follicles (J:140028)
• axes of hair shafts are randomly oriented, with some being horizontal to the skin layer (J:140028)
• axes of hair shafts are randomly oriented, with some being horizontal to the skin layer (J:140028)
• mice fail to grow vibrissae hairs (J:140028)
• mice fail to grow vibrissae hairs (J:140028)
• mice have thick skin with hyperplasia of the epidermis that is prone to injury (J:140028)
• mice have thick skin with hyperplasia of the epidermis that is prone to injury (J:140028)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hypotrichosis 6; HYPT6 607903 J:140028


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory