Phenotypes Associated with This Genotype

Genotype
MGI:3811362

• Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:157301 )

• at E14.5, the number of intermediate progenitor cells is decreased compared to in wild-type mice

abnormal neuron proliferation ( J:157301 )

• at E14.5, neuron proliferation in the cortex is reduced compared to in wild-type mice

abnormal forebrain morphology ( J:157301 )

• at E12.5, dorsal forebrain lengthening is observed unlike in wild-type mice

• at E14.5, the dorsal forebrain is longer and thinner than in wild-type mice

• however, treatment with all-trans retinoic acid restores forebrain morphology

abnormal cerebral cortex morphology ( J:157301 )

• at E18.5

abnormal stratification in cerebral cortex ( J:157301 )

• at E18.5, cortical layers are disorganized compared to in wild-type mice

abnormal brain meninges morphology ( J:157301 )

• at E14.5, meningeal cells end before the ventral forebrain with absent dorsal meninges unlike in wild-type mice

embryo

embryo phenotype ( J:91443 )

N • somites develop normally

cellular

abnormal neuron differentiation ( J:157301 )

• at E14.5, the number of intermediate progenitor cells is decreased compared to in wild-type mice

abnormal neuron proliferation ( J:157301 )

• at E14.5, neuron proliferation in the cortex is reduced compared to in wild-type mice