Phenotypes Associated with This Genotype

Genotype
MGI:3811310

• Allelic Composition: Xbp1^tm2Glm/Xbp1^tm2Glm; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:137188 )

• induced mice exhibit impaired triglyceride secretion from the liver, and significantly decreased de novo lipid (fatty acids and sterols) synthesis in the liver

decreased circulating triglyceride level ( J:137188 )

• at 3 weeks after cre induction with poly(I:C), plasma triglyceride levels are lower than in wild-type

decreased cholesterol level ( J:137188 )

• at 3 weeks after cre induction with poly(I:C), an almost complete absence of LDL-associated cholesterol in primary hepatocytes

decreased fatty acids level ( J:137188 )

• at 3 weeks after cre induction with poly(I:C), free fatty acid levels in isolated hepatocytes are reduced compared to wild-type controls