Phenotypes Associated with This Genotype

Genotype
MGI:3810471

• Allelic Composition: Adam17^tm1Bbl/Adam17^tm1Bbl; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased circulating tumor necrosis factor level ( J:139846 )

• TNF levels in the serum of mice expressing Cre are lower by more than half compared to controls 3 hours after LPS injection

decreased susceptibility to endotoxin shock ( J:139846 )

• two weeks after induction of Cre recombinase, mice are more resistant to endotoxin shock than in controls

• 6 of 8 mice survive endotoxin induction with LPS and D-galactosamine while 7 of 8 controls die within 16 hours of injection

homeostasis/metabolism

decreased circulating tumor necrosis factor level ( J:139846 )

• TNF levels in the serum of mice expressing Cre are lower by more than half compared to controls 3 hours after LPS injection