Phenotypes Associated with This Genotype

Genotype
MGI:3809749

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Gt(ROSA)26Sor^{tm6(Map3k14*)Rsky}/Gt(ROSA)26Sor^{tm6(Map3k14*)Rsky}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal Peyer's patch morphology ( J:139293 )

• lymphoid cells appear to spill over their normal confines into surrounding tissue unlike in wild-type mice

enlarged spleen ( J:139293 )

decreased B-1 B cell number ( J:139293 )

• in the peritoneal cavity

increased mature B cell number ( J:139293 )

• the spleen contains 6-fold more AA4.1-B cells than in control mice due to enhanced survival

• however, B cell proliferation is normal

abnormal spleen B cell follicle morphology ( J:139293 )

enlarged lymph nodes ( J:139293 )

hematopoietic system

enlarged spleen ( J:139293 )

decreased B-1 B cell number ( J:139293 )

• in the peritoneal cavity

increased mature B cell number ( J:139293 )

• the spleen contains 6-fold more AA4.1-B cells than in control mice due to enhanced survival

• however, B cell proliferation is normal

abnormal spleen B cell follicle morphology ( J:139293 )

growth/size/body

enlarged spleen ( J:139293 )

digestive/alimentary system

abnormal Peyer's patch morphology ( J:139293 )

• lymphoid cells appear to spill over their normal confines into surrounding tissue unlike in wild-type mice