Phenotypes Associated with This Genotype

Genotype
MGI:3809593

• Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn; Rps6ka4^tm1Jsca/Rps6ka4^tm1Jsca; Rps6ka5^tm1Jsca/Rps6ka5^tm1Jsca
• Genetic Background: B6.Cg-Il10^tm1Cgn Rps6ka5^tm1Jsca Rps6ka4^tm1Jsca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-10 secretion ( J:139576 )

• there is no IL-10 secretion from bone marrow derived macrophages after LPS stimulation

increased interleukin-12a secretion ( J:139576 )

• LPS stimulation of bone marrow derived macrophages leads to higher secretion of IL12a than in controls during an 8 hour time period

increased interleukin-12b secretion ( J:139576 )

• LPS stimulation of bone marrow derived macrophages leads to higher secretion of IL12b than in controls during an 8 hour time period

increased interleukin-6 secretion ( J:139576 )

• LPS stimulation of bone marrow derived macrophages leads to higher secretion of IL-6 than in controls during an 8 hour time period

increased tumor necrosis factor secretion ( J:139576 )

• LPS stimulation of bone marrow derived macrophages leads to higher secretion of TNF than in controls during an 8 hour time period