Rps6ka4^tm1Jsca
Targeted Allele Detail

Summary

• Symbol: Rps6ka4^tm1Jsca
• Name: ribosomal protein S6 kinase, polypeptide 4; targeted mutation 1, J Simon C Arthur
• MGI ID: MGI:3574670
• Synonyms: MSK2^-
• Gene: Rps6ka4 Location: Chr19:6806578-6818004 bp, - strand Genetic Position: Chr19, 5.08 cM
• Alliance: Rps6ka4^tm1Jsca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97140
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5-7, which encode amino acids 155-251 and make up the middle of the N-terminal kinase domain, were replaced with a neo. If readthrough occurred, splicing from exons 4-8 would result in a frameshift mutation. Immunoblotting of mutant MEFs confirmed the lack of protein. (J:97140)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6ka4 Mutation: 35 strains or lines available

References

• Original: J:97140 Wiggin GR, et al., MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol. 2002 Apr;22(8):2871-81
• All: 26 reference(s)