Phenotypes Associated with This Genotype

Genotype
MGI:3809306

• Allelic Composition: Dicer1^tm1Snj/Dicer1^tm1Snj; Tg(KRT5-cre/PGR)1Der/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:216813 )

• mice die as early as 6 months of age, with a mean survival of 16 months and 80% dying by 20 months of age

integument

alopecia ( J:139257 )

• at 2 to 3 months of age

progressive hair loss ( J:216813 )

• mice begin to lose their fur and whiskers shortly after the 5th week of age, by 10 weeks of age, mice only retain small patches of fur and are devoid of any fur at 3 months of age

abnormal hair follicle morphology ( J:216813 )

• interfollicular epidermis exhibits an increase in cellularity

• large amount of DNA damage in the basal layer of follicular epithelium and in the interfollicular epidermis

decreased hair follicle number ( J:216813 )

hair follicle degeneration ( J:216813 )

• hair follicles are debris-laden and mis-oriented and enlarged cells and apoptotic figures are seen surrounding the degraded follicle structure

loss of vibrissae ( J:216813 )

• mice begin to lose their whiskers shortly after the 5th week of age, by 10 weeks of age, mice show only a few misshapen whiskers, and mice are devoid of whiskers at 3 months of age

abnormal epidermal layer morphology ( J:139257 , J:216813 )

• at 2 to 3 months of age, mice exhibit a roughening of the epidermis (J:139257)

• cells are larger than in wild-type mice and display a senescence phenotype (J:139257)

• mice exhibit a roughened epidermis at 3 months of age (J:216813)

• interfollicular epidermis exhibits an increase in cellularity (J:216813)

thick epidermis ( J:216813 )

• increase in thickness of the epidermis with a mean thickness of 42 um compared to 24 um in controls

abnormal skin physiology ( J:216813 )

• increase in the numbers of apoptotic cells in the epidermis

• increase in the numbers of mitotic cells in the epidermis, indicating increased proliferation

growth/size/body

cachexia ( J:216813 )

• several mutants exhibit mild cachexia before death

neoplasm

neoplasm ( J:216813 )

N • no tumors are seen upon death