Phenotypes Associated with This Genotype

Genotype
MGI:3807512

• Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1.1Hon; Tg(Pax7-cre/ERT2)1Cbm/0
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:130251 )

• following treatment with tamoxifen, mice exhibit a reduction in the number of dIL^A neurons and an increased in the number of dIL^B neurons compared to in wild-type mice

abnormal neural tube morphology ( J:130251 )

• there is a decrease in the thickness of the progenitor zone in the neural tube of E13.5 embryos when tamoxifen is given at E10.5

• tamoxifen induction at E10.5 leads to about a 50% reduction in dIL^A neurons in newborns and about a 50% increase in dIL^B neurons

loss of GABAergic neurons ( J:130251 )

• following treatment with tamoxifen, mice exhibit a reduction in the number of dIL^A neurons compared to in wild-type mice

abnormal glutaminergic neuron morphology ( J:130251 )

• following treatment with tamoxifen, mice exhibit an increased in the number of dIL^B neurons compared to in wild-type mice

decreased neuronal precursor cell number ( J:130251 )

• at E13.5 following treatment with tamoxifen, the progenitor domain is reduced compared to in wild-type mice

embryo

abnormal neural tube morphology ( J:130251 )

• there is a decrease in the thickness of the progenitor zone in the neural tube of E13.5 embryos when tamoxifen is given at E10.5

• tamoxifen induction at E10.5 leads to about a 50% reduction in dIL^A neurons in newborns and about a 50% increase in dIL^B neurons

cellular

abnormal neuron differentiation ( J:130251 )

• following treatment with tamoxifen, mice exhibit a reduction in the number of dIL^A neurons and an increased in the number of dIL^B neurons compared to in wild-type mice