Phenotypes Associated with This Genotype

Genotype
MGI:3805708

• Allelic Composition: Pdss2^tm1Dalg/Pdss2^tm1Dalg; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal mitophagy ( J:136670 )

• increased autophagy of mitochondria

abnormal circulating cholesterol level ( J:136670 )

• elevated plasma cholesterol

abnormal energy homeostasis ( J:136670 )

• many biochemical pathways involved in energy production are upregulated

cellular

abnormal mitophagy ( J:136670 )

• increased autophagy of mitochondria

abnormal aerobic respiration ( J:136670 )

• impaired mitochondrial respiration

abnormal respiratory electron transport chain ( J:136670 )

• significant decrease in complex I and complex II-dependent respiratory chain capacity in liver