Analysis Tools
behavior/neurological
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• long-term memory for contextual conditioning is significantly impaired compared to wild-type controls
• overtraining does not rescue defect as mice continue to display less freezing behavior than wild-type littermates
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• long-term memory for cued conditioning is significantly impaired compared to wild-type controls
• overtraining does not rescue defect as mice continue to display less freezing behavior than wild-type littermates
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nervous system
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• cellular density appears greater throughout cortex, but laminar organization is normal
• at P10 mice show a 10% reduction in neuron number in cerebral cortex, with a 40% increase in non-neuronal, presumptive glial cells
• neuron number in layer VI and cortical preplate is reduced by 35%at P2
• in layer V, there are only 50% as many neurons as in wild-type at P2
• layers II-IV show a 30% decrease in neurons at P2
• dramatic increase in astrocyte number is observed throughout cortex and subventricular zone
• astrocyte metabolism and viability are similar to wild-type; neuronal apoptosis and differentiation are similar to controls
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• cortical thickness is significantly reduced throughout the dorsal telencephalon relative to wild-type at P2
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cellular
